- Somatic pathogenic variants in BRAF, EGFR, KRAS and NRAS genes may influence cancer therapies. The identification of such pathogenic variants in these genes allows targeted treatment and stratification of cancer patients.
- Genetic variants of genes involved in drug metabolism (e.g. DPYD and TPMT) can significantly alter the response to chemotherapeutic treatment.
- The impact of specific genetic variants are covered in current guidelines for the respective type of cancer.