ViennaLab Diagnostics GmbH

Reduce severe side effects of fluoropyrimidine (e.g. 5-FU) treatment by DPYD genotyping.

Fluoropyrimidines are widely used for the treatment of various solid tumors. The PGX-5FU XL StripAssay® covers the four most clinically relevant variants in the dihydropyrimidine dehydrogenase (DPYD) gene with therapeutic relevance for fluoropyrimidine treatment as recommended by the European Medicines Agency in April 2020.




  • Fluoropyrimidines (5-Fluorouracil, Capecitabine and Tegafur) are frequently used in cancer therapy. However, some patients develop severe treatment-related toxicity.
  • A part of fluoropyrimidine-related toxicity arises due to impaired activity of the key metabolic enzyme dihydropyrimidine dehydrogenase (DPD) caused by genetic variants in the DPYD gene.
  • CPIC Guidelines recommend DPYD genotype-guided fluoropyrimidine dosing to increase patient safety.

Link to CPIC Guidelines


ProductReg. Stat.REFUnit SizeIFUBrochure
PGX-5FU XL StripAssay® CE/IVD4-78020 tests



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