ViennaLab Diagnostics GmbH

Determine genetic variants and copy number changes associated with a poor, intermediate or ultra-rapid CYP2D6 metabolizer status.

Differences in the activity of the liver enzyme CYP2D6 contribute to the inter-individual variability in a majority of drug responses.The PGX-CYP2D6 XL StripAssay® in combination with the CYP2D6 RealFastTM CNV Assay detects the most relevant variations (genetic variants as well as copy number changes) in different populations including European, American, Central/South Asian, Latino, Sub-Saharan African, and many more which are associated with a poor, intermediate or ultrarapid CYP2D6 metabolizer status.

PGX-CYP2D6

 

  • CYP2D6 is involved in the metabolism of about 25% of all drugs used in the clinic (e.g. tamoxifen, opiates, antidepressives or antipsychotics).
  • CYP2D6 loss-of-function alleles: *3 - *8, *11, *12, *15, *40, *69, *114.
  • CYP2D6 reduced function alleles: *9, *10, *14, *17, *29, *41.
  • CYP2D6 increased function alleles: *1xN, *2xN, *35xN (N= copy number).
  • Clinical guidelines on drug prescription recommendations are listed on PharmGKB: www.pharmgkb.org.
  • The PGX-CYP2D6 XL StripAssay® in combination with the CYP2D6 RealFastTM CNV Assay identifies patients with altered CYP2D6 enzyme function. This facilitates the choice of medication and/or the adjustment of drug dosage, thereby reducing the risk of adverse events or lowered treatment efficacy.

 

Assay coverage for the given human populations

European (0.94), African American/Afro Caribbean (0.81), American (0.95), Central/South Asian (0.94), East Asian (0.92), Latino (0.93), Near Eastern (0.94), Oceanian (0.98), Sub-Saharan African (0.84).

 

ProductReg. Stat.REFUnit SizeIFUBrochure
PGX-CYP2D6 XL StripAssay® CE/IVD4-77020 tests

PDF

PDF

CYP2D6 RealFast™ CNV Assay CE/IVD7-420100 rxn

PDF

PDF

We use Matomo to analyze the access to our website. We pass on information about your use of our website to our partners for analysis. Our partners may combine this information with other data that you have provided to them or that they have collected as part of your use of the services. I agree.

Deny