Familial Mediterranean Fever (FMF) is characterized by recurrent episodes of fever accompanied by painful inflammatory events. The FMF StripAssays^®  identify the most frequent disease-causing variants in the MEFV gene and risk factors for AA amyloidosis.

Familial Mediterranean Fever (FMF)

• FMF is the most prevalent monogenic autoinflammatory disease mainly affecting people of Mediterranean descent.
• Mutations in the MEFV gene were found to underlie the development of FMF.
• A severe long-term complication is systemic reactive (AA) amyloidosis, which is characterized by extracellular deposition of proteolytic fragments of serum amyloid A (SAA) ultimately leading to organ damage.
• The homozygous condition of the SAA isotype SAA1.1 is significantly linked to AA amyloidosis in patients with FMF.