Specific Apolipoprotein E variants have been associated with type III hyperlipoproteinemia (ApoE2), cardiovascular disease and Alzheimer’s disease (ApoE4). ViennaLab Apo E StripAssay® easily discriminates between the E2, E3, and E4 variants of ApoE.
ApoE
- ApoE has key roles in the transport of cholesterol and other lipids within blood circulation and the central nervous system.
- ApoE is polymorphic exhibiting three different alleles, which differ by an alternating combination of two amino acids at position 112 and 158: E2 (C112_C158), E3 (C112_R158) and E4 (R112_R158)
- ApoE is an important predictor of the plasma lipid profile. On average, LDL-cholesterol concentrations are lower for E2 carriers and higher for E4 carriers compared to homozygous E3 carriers.
- ApoE2 and ApoE4 have been associated with an increased risk for Cardiovascular Disease (E2), and susceptibility to Alzheimer’s Disease and Coronary Artery Disease (E4) in various studies.
- Identifying genetic variations in combination with timely life style adaptations may contribute to delay of disease onset.
pdf Productnote 01: CVD Marker