Discriminate between ApoE variants associated with type III hyperlipoproteinemia, cardiovascular disease and Alzheimer’s disease.

Specific Apolipoprotein E variants have been associated with type III hyperlipoproteinemia (ApoE2), cardiovascular disease and Alzheimer’s disease (ApoE4). ViennaLab Apo E StripAssay® easily discriminates between the E2, E3, and E4 variants of ApoE.

 

ApoE

 

  • ApoE has key roles in the transport of cholesterol and other lipids within blood circulation and the central nervous system.
  • ApoE is polymorphic exhibiting three different alleles, which differ by an alternating combination of two amino acids at position 112 and 158: E2 (C112_C158), E3 (C112_R158) and E4 (R112_R158)
  • ApoE is an important predictor of the plasma lipid profile. On average, LDL-cholesterol concentrations are lower for E2 carriers and higher for E4 carriers compared to homozygous E3 carriers.
  • ApoE2 and ApoE4 have been associated with an increased risk for Cardiovascular Disease (E2), and susceptibility to Alzheimer’s Disease and Coronary Artery Disease (E4) in various studies.
  • Identifying genetic variations in combination with timely life style adaptations may contribute to delay of disease onset.

 

ProductREFUnit SizeIFUBrochure
Apo E StripAssay®4-28020 tests

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